A vial with the Johnson & Johnson’s one-dose COVID-19 vaccine is seen at the Vaxmobile, at the Uniondale Hempstead Senior Center, Wednesday, March 31, 2021, in Uniondale, N.Y. THE CANADIAN PRESS/AP/Mary Altaffer

A vial with the Johnson & Johnson’s one-dose COVID-19 vaccine is seen at the Vaxmobile, at the Uniondale Hempstead Senior Center, Wednesday, March 31, 2021, in Uniondale, N.Y. THE CANADIAN PRESS/AP/Mary Altaffer

What we know about J&J’s single-dose vaccine, set to arrive at the end of April

Canada approved the vaccine in early March and had pre-ordered 10 million doses

Canada will soon add another COVID-19 vaccine to its supply, with procurement minister Anita Anand announcing this week that initial shipments of Johnson & Johnson’s single-dose jab are to arrive by the end of April.

Canada approved the vaccine in early March and had pre-ordered 10 million doses, but manufacturing problems from the company led to shipment delays to Canada and elsewhere.

Anand did not have details when she made her announcement Tuesday about how many doses would be included in the first shipment.

Johnson & Johnson gives Canada four distinct vaccines — along with Pfizer-BioNTech, Moderna and Oxford-AstraZeneca — and its one-and-done element adds flexibility to the country’s plan to immunize the majority of its residents by September.

Dr. Sumon Chakrabarti, an infectious disease expert in Mississauga, Ont., says that while the vaccines are arriving later than expected, they’ll be a welcome addition to Canada’s rollout.

“A single-dose vaccine, as well as the fact it only requires a regular fridge (to store it), that is so huge in terms of taking this vaccine and bringing it to targeted populations,” he said. “I wish it was (arriving before) the end of April, but I’ll take it.”

Johnson & Johnson hit another manufacturing bump Wednesday, announcing that a batch of its vaccine had failed quality standards and can’t be used.

The drugmaker didn’t say how many doses were lost, and it wasn’t clear how the problem would impact future deliveries.

Here’s what we know about Johnson & Johnson’s vaccine:

HOW EFFECTIVE IS IT?

Johnson & Johnson announced promising results from its Phase 3 clinical trials at the end of January, suggesting its vaccine reduced severe COVID-19 disease by 85 per cent, and prevented 100 per cent of COVID-related hospitalization or death.

The vaccine had a 72 per cent efficacy in preventing COVID infections after 28 days in the company’s U.S. trials. The efficacy dropped to 66 per cent when averaging in results from other global trials, including a South African study that factored in more transmissible variants of the COVID virus.

Pfizer and Moderna showed 95 per cent efficacy in their respective trials, but those were tested against previous dominant strains and didn’t account for variants that have popped up since.

Pfizer, Moderna and AstraZeneca also had zero hospitalizations and deaths in their trials.

Chakrabarti says it’s important to distinguish the timing of the four trials, and stressed that they all work exceedingly well the metrics that matter most.

“All four of these vaccines … are exceptionally effective at preventing hospitalization and death,” he said. “Those are the two things that we care about.”

WHAT ARE THE BENEFITS OF THIS VACCINE?

The ease of distribution offered by a single-dose shot — unlike the two-dose vaccines from Pfizer, Moderna and AstraZeneca — and its ability to be stored in a regular fridge are among Johnson & Johnson’s biggest strengths.

Pfizer’s vaccine initially required ultra-cold storage temperatures between -60 C and -80 C, though Health Canada recently said it could be stored in a regular freezer for up to 14 days. Moderna’s vaccine can also be stored at regular freezer temperatures while AstraZeneca can be stored in a fridge.

Chakrabarti says Johnson & Johnson’s product is conducive to large, mobile vaccine clinics that can be set up quickly to target populations in hard-hit communities, especially essential workers.

“You can transport the vaccine there and just boom, boom, boom, get it into people’s arms,” he said. “The timing doesn’t help — we really wanted to start (vaccinating) essential workers as quickly as possible … But it’s something you can do (easily) with J&J.”

Chakrabarti added that Johnson & Johnson may also benefit from not having the string of confusing messaging surrounding it that AstraZeneca has had.

Canada’s National Advisory Committee on Immunization (NACI) has set age recommendations on AstraZeneca three times. The latest recommendation is to pause the use of AstraZeneca in those under 55 due to rare blood clot links that were observed in Europe.

READ MORE: Trudeau says Johnson & Johnson vaccine faces production challenges

Omar Khan, an assistant professor in biomedical engineering at the University of Toronto, says Johnson & Johnson could slot into the void left by provinces not using AstraZeneca on those under 55.

“That (decision by NACI) effectively reduced our vaccine supply,” Khan said. “But with this we can make up that loss of supply for that population and hopefully get us back on track.”

The fact that Johnson & Johnson is already in use in the U.S. may give Canadians more confidence in it, Chakrabarti says.

The FDA authorized Johnson & Johnson on Feb. 27 for emergency use — just as it had for Pfizer and Moderna in December — but shipments to the U.S. were also affected by manufacturing problems early on. The bulk of vaccine use in the U.S. has been Pfizer and Moderna.

“It’s very good when you see other countries having experience with it,” he said, adding that a mountain of positive AstraZeneca data also exists from the U.K., as well as data from Israel on the high effectiveness of Pfizer.

WHAT KIND OF VACCINE TECHNOLOGY IS USED?

Unlike the mRNA used in Pfizer and Moderna’s products, Johnson & Johnson is a non-replicating viral vector vaccine similar to AstraZeneca’s.

That means it uses a different harmless virus, which can’t copy itself, as a vector to give our cells the instructions they need to make the coronavirus’s spike protein.

The immune system recognizes the protein and makes antibodies, which then allow us to fend off attack if exposed in the future.

Khan says it takes a couple weeks for the body to build up immunity with any of the vaccines, but those receiving Johnson & Johnson should especially take note of that.

“Yes, it’s one dose so people might say ‘one and done, ready to go,’ but you still need to give yourself the bare minimum two weeks,” he said. “Ideally, give yourself a month, and then you’ll have a higher level of protection.”

Melissa Couto Zuber, The Canadian Press


Like us on Facebook and follow us on Twitter.

Want to support local journalism during the pandemic? Make a donation here.

Coronavirusvaccines

Get local stories you won't find anywhere else right to your inbox.
Sign up here

Just Posted

School District 83 trustees are expected to be discussing the current Long Range Facilities Plan options at the April 20 school board meeting. (File photo)
Letter: Let the people have their say on Salmon Arm school options

Parent encourages School District 83 board to hold off on making a decision

South Shuswap. (Google Maps)
CSRD to ask school trustees to delay decision on Salmon Arm high school options

South Shuswap director advocating for Sorrento high school option

Elvira D’Angelo, 92, waits to receive her COVID-19 vaccination shot at a clinic in Montreal, Sunday, March 7, 2021, as the COVID-19 pandemic continues in Canada and around the world. THE CANADIAN PRESS/Graham Hughes
110 new cases of COVID-19 in Interior Health

Provincial health officers announced 1,005 new cases throughout B.C.

Public input on the City of Enderby’s proposed 2021 budget is open until 3:30 p.m. Monday, April 19, 2021. (City of Enderby photo)
Enderby’s proposed 2021 budget open for public input

The proposed spending plan includes a 2.2 per cent tax increase; public input open until Monday

Glenn Moyer is seeking space on a public wharf in Sicamous in order to restart his water taxi business after a year-long shutdown due to COVID-19. (Glenn’s Water Taxi/Facebook)
Water taxi operator requests public dock moorage in Sicamous

Glenn Moyer, a long time water taxi operator, is brimming with stories of life on the lake

Flow Academy is located at 1511 Sutherland Avenue in Kelowna. (Michael Rodriguez - Capital News)
Black Press Media Weekly Roundup: Top headlines this week

Here’s a quick roundup of the stories that made headlines across the Okanagan, from April 11 to 16

A Western toadlet crosses the centre line of Elk View Road in Chilliwack on Aug. 26, 2010. A tunnel underneath the road has since been installed to help them migrate cross the road. Saturday, April 24 is Save the Frogs Day. (Jenna Hauck/ Progress File)
Unofficial holidays: Here’s what people are celebrating for the week of April 18 to 24

Save the Frogs Day, Love Your Thighs Day and Scream Day are all coming up this week

An Extinction Rebellion Vancouver Island (XRVI) climate change event in 2019 saw a large crowd occupy the Johnson Street bridge. Black Press File Photo
‘In grief for our dying world’: B.C. climate activists embark on 4-day protest

demonstrators will walk through Vancouver for the first two days before boarding a ferry Sunday morning

A vial of some of the first 500,000 of the two million AstraZeneca COVID-19 vaccine doses that Canada secured. THE CANADIAN PRESS/Carlos Osorio
Canada’s 2nd blood clot confirmed in Alberta after AstraZeneca vaccine

Thw male patient, who is in his 60s, is said to be recovering

Valen a student of Coldstream Elementary writes advice for adults amid a pandemic.
‘We can get rid of COVID together’: B.C. kids share heartwarming advice

Elementary students share their wisdom to adults in unprecedented times

Mervin Mascarenhas giving one of his pens to Honorary JP-MP. Premier David Burt of Bermuda. (Image: Mervin Mascarenhas)
Kelowna man who made $90K ‘Space Pen’ recognized by dignitaries, sheikhs

Mervin Mascarenhas is the first Canadian to grace the cover of Millennium Millionaire Magazine

The funeral of Britain’s Prince Philip in Windsor, England, on Saturday, April 17, 2021. Philip died April 9 at the age of 99. (Kirsty Wigglesworth/AP)
PHOTOS: Prince Philip laid to rest Saturday as sombre queen sits alone

The entire royal procession and funeral took place out of public view within the grounds of Windsor Castle

B.C. Health Minister Adrian Dix and Premier John Horgan describe vaccine rollout at the legislature, March 29, 2021. (B.C. government)
B.C. health minister says delay in Moderna vaccine ‘disappointing’

‘The sooner we get vaccines in people’s arms the better, and inconsistency in delivery is a consistent problem. This is simply a reality and not an issue of blame,’ Adrian Dix said Friday

(Police handout/Kamloops RCMP)
B.C. man dies in custody awaiting trial for Valentine’s Day robbery, kidnapping spree

Robert James Rennie, who was on the Kamloops RCMP’s most wanted list, passed away at the North Fraser Pretrial Centre in Coquitlam

Most Read